SCCS – Opinion on the safety of Acetophenone & Scientific Advice on CBD

Posted Date: 5-May-2026

EU Corrigendum on Fragrance Allergens

 

The SCCS considers Acetophenone safe, when present as a constituent of natural complex substances that are used in cosmetic products, provided that its concentration does not exceed 100 ppm (0.01%) in the finished cosmetic product. In light of the data provided and taking into consideration the possible classification as ‘Repr.1B’ under Regulation (EC) No 1272/2008 (CLP Regulation), the SCCS considers Acetophenone safe when present up to a maximum concentration of 100 ppm (0.01%) in cosmetic products, taking also into account sources of exposure other than cosmetics (food, tobacco smoking).

 

Scientific Advice on Cannabidiol (CBD)

 

Based on the limited available data, the SCCS considers CBD safe when used at concentrations up to 0.19% in dermal cosmetic products and oral cosmetic products – whether used separately or in combination.

 

The SCCS considers the presence of THC impurities as safe at concentrations up to 0.00025% in dermal and oral cosmetic products – whether used separately or in combination.

 

The SCCS acknowledges that the current evaluation may have some limitations because of the paucity of data/information received from a few respondents to the Commission’s Call for data. These limitations can be addressed as and when adequate data / information can be made available by interested Applicants.